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Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with D-Chiro-Inositol.
- Source :
-
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2015 May; Vol. 291 (5), pp. 1181-6. Date of Electronic Publication: 2014 Nov 22. - Publication Year :
- 2015
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Abstract
- Purpose: To evaluate the effects of D-Chiro-Inositol in women affected by polycystic ovary syndrome (PCOS).<br />Methods: We enrolled 48 patients, with homogeneous bio-physical characteristics, affected by PCOS and menstrual irregularities. These patients underwent treatment with 1 gr of D-Chiro-Inositol/die plus 400 mcg of Folic Acid/die orally for 6 months. We analyzed pre-treatment and post-treatment BMI, Systolic and Diastolic blood pressure, Ferriman-Gallwey score, Cremoncini score, serum LH, LH/FSH ratio, total and free testosterone, DHEA-S, Δ-4-androstenedione, SHBG, prolactin, glucose/IRI ratio, HOMA index, and resumption of regular menstrual cycles.<br />Results: We evidenced a statistically significant reduction of systolic blood pressure, Ferriman-Gallwey score, LH, LH/FSH ratio, total Testosterone, free Testosterone, ∆-4-Androstenedione, Prolactin, and HOMA Index; in the same patients, we noticed a statistically significant increase of SHBG and Glycemia/IRI ratio. Moreover, we observed statistically significant (62.5%; p < 0.05) post-treatment menstrual cycle regularization.<br />Conclusions: D-Chiro-Inositol is effective in improving ovarian function and metabolism of patients affected by PCOS.
- Subjects :
- Adult
Blood Glucose
Female
Folic Acid therapeutic use
Follicle Stimulating Hormone blood
Humans
Inositol therapeutic use
Luteinizing Hormone blood
Menstrual Cycle blood
Menstrual Cycle drug effects
Menstruation Disturbances blood
Metrorrhagia etiology
Metrorrhagia prevention & control
Middle Aged
Oligomenorrhea etiology
Oligomenorrhea prevention & control
Polycystic Ovary Syndrome blood
Polycystic Ovary Syndrome metabolism
Prolactin blood
Prospective Studies
Testosterone blood
Treatment Outcome
Vitamin B Complex therapeutic use
Young Adult
Folic Acid administration & dosage
Inositol pharmacology
Menstruation Disturbances drug therapy
Ovary physiopathology
Polycystic Ovary Syndrome drug therapy
Vitamin B Complex pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-0711
- Volume :
- 291
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Archives of gynecology and obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 25416201
- Full Text :
- https://doi.org/10.1007/s00404-014-3552-6