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Identification of people with autosomal dominant polycystic kidney disease using routine data: a cross sectional study.
- Source :
-
BMC nephrology [BMC Nephrol] 2014 Nov 20; Vol. 15, pp. 182. Date of Electronic Publication: 2014 Nov 20. - Publication Year :
- 2014
-
Abstract
- Background: Autosomal dominant polycystic kidney disease (ADPKD) causes progressive renal damage and is a leading cause of end-stage renal failure. With emerging therapies it is important to devise a method for early detection. We aimed to identify factors from routine clinical data which can be used to distinguish people with a high likelihood of having ADPKD in a primary health care setting.<br />Method: A cross-sectional study was undertaken using data from the Quality Intervention in Chronic Kidney Disease trial extracted from 127 primary care practices in England. The health records of 255 people with ADPKD were compared to the general population. Logistic regression was used to identify clinical features which distinguish ADPKD. These clinical features were used to stratify individual risk using a risk score tool.<br />Results: Renal impairment, proteinuria, haematuria, a diastolic blood pressure over 90 mmHg and multiple antihypertensive medications were more common in ADPKD than the general population and were used to build a regression model (area under the receiver operating characteristic curve; 0.79). Age, gender, haemoglobin and urinary tract infections were not associated with ADPKD. A risk score (range -3 to +10) of ≥0 gave a sensitivity of 70.2% and specificity 74.9% of for detection.<br />Conclusions: Stratification of ADPKD likelihood from routine data may be possible. This approach could be a valuable component of future screening programs although further longitudinal analyses are needed.
- Subjects :
- Adolescent
Adult
Age Factors
Antihypertensive Agents therapeutic use
Cross-Sectional Studies
Drug Therapy, Combination
Early Diagnosis
England
Female
Hematuria etiology
Humans
Hypertension, Renal drug therapy
Hypertension, Renal etiology
Kidney Function Tests
Logistic Models
Male
Middle Aged
Polycystic Kidney, Autosomal Dominant complications
Polycystic Kidney, Autosomal Dominant urine
Predictive Value of Tests
Primary Health Care
Proteinuria etiology
Renal Insufficiency, Chronic epidemiology
Renal Insufficiency, Chronic etiology
Risk Assessment
Risk Factors
Sensitivity and Specificity
Young Adult
Biomarkers analysis
Mass Screening methods
Polycystic Kidney, Autosomal Dominant diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2369
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- BMC nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 25412767
- Full Text :
- https://doi.org/10.1186/1471-2369-15-182