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Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study.
- Source :
-
PloS one [PLoS One] 2014 Nov 20; Vol. 9 (11), pp. e113366. Date of Electronic Publication: 2014 Nov 20 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Background and Aims: L-glutamine is an efficacious glucagon-like peptide (GLP)-1 secretagogue in vitro. When administered with a meal, glutamine increases GLP-1 and insulin excursions and reduces postprandial glycaemia in type 2 diabetes patients. The aim of the study was to assess the efficacy and safety of daily glutamine supplementation with or without the dipeptidyl peptidase (DPP)-4 inhibitor sitagliptin in well-controlled type 2 diabetes patients.<br />Methods: Type 2 diabetes patients treated with metformin (n = 13, 9 men) with baseline glycated hemoglobin (HbA1c) 7.1±0.3% (54±4 mmol/mol) received glutamine (15 g bd)+ sitagliptin (100 mg/d) or glutamine (15 g bd) + placebo for 4 weeks in a randomized crossover study.<br />Results: HbA1c (P = 0.007) and fructosamine (P = 0.02) decreased modestly, without significant time-treatment interactions (both P = 0.4). Blood urea increased (P<0.001) without a significant time-treatment interaction (P = 0.8), but creatinine and estimated glomerular filtration rate (eGFR) were unchanged (P≥0.5). Red blood cells, hemoglobin, hematocrit, and albumin modestly decreased (P≤0.02), without significant time-treatment interactions (P≥0.4). Body weight and plasma electrolytes remained unchanged (P≥0.2).<br />Conclusions: Daily oral supplementation of glutamine with or without sitagliptin for 4 weeks decreased glycaemia in well-controlled type 2 diabetes patients, but was also associated with mild plasma volume expansion.<br />Trial Registration: ClincalTrials.gov NCT00673894.
- Subjects :
- Administration, Oral
Aged
Diabetes Mellitus, Type 2 metabolism
Diabetes Mellitus, Type 2 physiopathology
Drug Administration Schedule
Drug Therapy, Combination
Female
Glutamine therapeutic use
Glycated Hemoglobin metabolism
Humans
Hypoglycemic Agents adverse effects
Hypoglycemic Agents therapeutic use
Male
Metformin administration & dosage
Metformin therapeutic use
Middle Aged
Plasma Volume drug effects
Sitagliptin Phosphate therapeutic use
Treatment Outcome
Diabetes Mellitus, Type 2 drug therapy
Glutamine administration & dosage
Glutamine adverse effects
Hypoglycemic Agents administration & dosage
Sitagliptin Phosphate administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25412338
- Full Text :
- https://doi.org/10.1371/journal.pone.0113366