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Bovine leukemia virus (BLV)-infected B-cells express a marker similar to the CD5 T cell marker.
- Source :
-
Immunology letters [Immunol Lett] 1989 Jan 15; Vol. 20 (1), pp. 69-76. - Publication Year :
- 1989
-
Abstract
- In the course of generating monoclonal antibodies to bovine thymus-dependent differentiation antigens, we were able to characterize an antibody, termed 8C11, that detects an antigen shared by a majority of thymocytes and peripheral T cells (in blood and thymus-dependent area of spleen and lymph-nodes), but undetectable on normal B cells. However, this antibody was reactive with B cells from cows infected with bovine leukemia virus (BLV). These BLV-infected B cells were found to express simultaneously high concentrations of both surface IgM and 8C11-detected antigen. The antigen recognized by this antibody was shown to be a 67.5 kDa molecule. Because similar findings have been made on mouse myelomas and on human chronic leukemia cells, where this antigen was considered to be the equivalent of mouse Ly-1 antigen and human Leu-1 or CD5 antigen, the T cell antigen detected on BLV-infected cells could be the bovine counterpart of the CD5 antigen. By another way, it has been found that the CD5 T cell antigen is also present on a minor subpopulation of B cells in the spleen but not in the blood. We suggest that in the bovine a similar B cell subpopulation should be the BLV target and expand as a consequence of viral insertion, leading to the persistent lymphocytosis observed on BLV-infected animals.
- Subjects :
- Animals
Antibody Specificity
B-Lymphocytes microbiology
Cattle Diseases pathology
Cross Reactions
Female
Leukemia immunology
Leukemia pathology
Antibodies, Monoclonal immunology
Antigens, Differentiation, T-Lymphocyte immunology
Antigens, Neoplasm immunology
Antigens, Surface immunology
B-Lymphocytes immunology
Cattle immunology
Cattle Diseases immunology
Leukemia veterinary
Leukemia Virus, Bovine immunology
Retroviridae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-2478
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 2541078
- Full Text :
- https://doi.org/10.1016/0165-2478(89)90071-0