In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.

Authors :: Baraka V
Tinto H
Valea I
Fitzhenry R
Delgado-Ratto C
Mbonye MK
Van Overmeir C
Rosanas-Urgell A
Van Geertruyden JP
D'Alessandro U
Erhart A
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Jan; Vol. 59 (1), pp. 734-7. Date of Electronic Publication: 2014 Nov 17.
Publication Year :: 2015
Abstract: Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

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