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Inhibition of three novel Radix Scutellariae extracts on immediate hypersensitivity.
- Source :
-
African journal of traditional, complementary, and alternative medicines : AJTCAM [Afr J Tradit Complement Altern Med] 2014 Aug 23; Vol. 11 (5), pp. 54-60. Date of Electronic Publication: 2014 Aug 23 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Background: Radix Scutellariae, a few papers reported its pharmacology activities including alleviate small intestines smooth muscles spasm, sedation, antihypertensive effect. However, the inhibition of its different organic extracts on immediate hypersensitivity has not bee researched.<br />Materials and Methods: To investigate the anti-immediate hypersensitivity of three extracts including ethanol extracts, acetone extracts, ethyl acetate extracts from Radix Scutellariae, four pharmacological screening model were chose, such as 4-Aminopyridine induced pruritus model, histamine-induced mouse paw edema model, PCA(passive cutaneous anaphylaxis) in ear of mouse, activie cutaneous anaphylaxismouse (mouse ear edema test), furthermore, total IgE level in the sensitized mice serum was evaluated deeply.<br />Results: Ethanol group at 1.42 g/kg and 0.71 g/kg could greatly decrease the licking number to 1.2 and 12.7 respectively; also keep mice paw swelling at 0.29 ml and 0.51 ml at 15 min after injection of histamine. Both ear passive cutaneous allergic reaction and active cutaneous anaphylaxis-ear swelling test demonstrated that ethanol group exhibit great inhibition on immediate hypersensitivity.Low IgE level was found in ethanol group, but high in other two groups.<br />Conclusion: The ethanol extracts exhibits obvious strong inhibition, however, the acetone ones and ethyl acetate showed a little.
- Subjects :
- Aminopyridines
Anaphylaxis blood
Animals
Anti-Allergic Agents pharmacology
Behavior, Animal
Drugs, Chinese Herbal pharmacology
Ear
Edema chemically induced
Edema drug therapy
Female
Hypersensitivity, Immediate blood
Hypersensitivity, Immediate drug therapy
Hypersensitivity, Immediate pathology
Immunoglobulin E blood
Male
Mice
Plant Roots
Skin pathology
Anaphylaxis drug therapy
Anti-Allergic Agents therapeutic use
Drugs, Chinese Herbal therapeutic use
Passive Cutaneous Anaphylaxis drug effects
Phytotherapy
Scutellaria baicalensis
Skin drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2505-0044
- Volume :
- 11
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- African journal of traditional, complementary, and alternative medicines : AJTCAM
- Publication Type :
- Academic Journal
- Accession number :
- 25395705
- Full Text :
- https://doi.org/10.4314/ajtcam.v11i5.9