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Evaluation of the Pulmonary Toxicity of a Fume Generated from a Nickel-, Copper-Based Electrode to be Used as a Substitute in Stainless Steel Welding.
- Source :
-
Environmental health insights [Environ Health Insights] 2014 Oct 15; Vol. 8 (Suppl 1), pp. 11-20. Date of Electronic Publication: 2014 Oct 15 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Epidemiology has indicated a possible increase in lung cancer among stainless steel welders. Chromium (Cr) is a primary component of stainless steel welding fume. There is an initiative to develop alternative welding consumables [nickel (Ni)- and copper (Cu)-based alloys] that do not contain Cr. No study has been performed to evaluate the toxicity of fumes generated from Ni- and Cu-based consumables. Dose-response and time-course effects on lung toxicity of a Ni- and Cu-based welding fume (Ni-Cu WF) were examined using an in vivo and in vitro bioassay, and compared with two other well-characterized welding fumes. Even though only trace amounts of Cr were present, a persistent increase in lung injury and inflammation was observed for the Ni-Cu WF compared to the other fumes. The difference in response appears to be due to a direct cytotoxic effect by the Ni-Cu WF sample on lung macrophages as opposed to an elevated production of reactive oxygen species (ROS).
Details
- Language :
- English
- ISSN :
- 1178-6302
- Volume :
- 8
- Issue :
- Suppl 1
- Database :
- MEDLINE
- Journal :
- Environmental health insights
- Publication Type :
- Academic Journal
- Accession number :
- 25392698
- Full Text :
- https://doi.org/10.4137/EHI.S15260