Back to Search
Start Over
Notch2 signaling in mast cell development and distribution in the intestine.
- Source :
-
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2015; Vol. 1220, pp. 79-89. - Publication Year :
- 2015
-
Abstract
- Notch signaling controls cell-fate specification events in various types of blood cells, and it further regulates the function of particular blood cells. Recent studies have identified the role of Notch signaling as a determinant of mast cell fate from bone marrow progenitors and mast cell maturation towards mucosal type rather than connective tissue type. Furthermore, Notch2 has functional properties for immune defense against Strongyloides venezuelensis through properly distributing intestinal mast cells. The goal of this chapter is to provide the researchers with the comprehensive protocols to examine the functions of Notch signaling in mast cells both in vitro and in vivo.
- Subjects :
- Animals
Calcium-Binding Proteins
Cell Differentiation drug effects
Cell Proliferation drug effects
Chymases metabolism
Gene Deletion
Gene Expression Regulation, Enzymologic drug effects
Gene Transfer Techniques
Humans
Intercellular Signaling Peptides and Proteins pharmacology
Intestines parasitology
Ligands
Male
Mast Cells drug effects
Mast Cells immunology
Methylcellulose chemistry
Myeloid Progenitor Cells cytology
Myeloid Progenitor Cells drug effects
Protein Transport
Rats
Receptor, Notch2 deficiency
Receptor, Notch2 genetics
Retroviridae genetics
Strongyloides physiology
Intestines immunology
Mast Cells cytology
Receptor, Notch2 metabolism
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1940-6029
- Volume :
- 1220
- Database :
- MEDLINE
- Journal :
- Methods in molecular biology (Clifton, N.J.)
- Publication Type :
- Academic Journal
- Accession number :
- 25388246
- Full Text :
- https://doi.org/10.1007/978-1-4939-1568-2_6