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Phototherapy promotes healing of cutaneous wounds in undernourished rats.
- Source :
-
Anais brasileiros de dermatologia [An Bras Dermatol] 2014 Nov-Dec; Vol. 89 (6), pp. 899-904. - Publication Year :
- 2014
-
Abstract
- Background: Various studies have shown that phototherapy promotes the healing of cutaneous wounds.<br />Objective: To investigate the effect of phototherapy on healing of cutaneous wounds in nourished and undernourished rats.<br />Methods: Forty rats, 20 nourished plus 20 others rendered marasmus with undernourishment, were assigned to four equal groups: nourished sham, nourished Light Emitting Diode treated, undernourished sham and undernourished Light Emitting Diode treated. In the two treated groups, two 8-mm punch wounds made on the dorsum of each rat were irradiated three times per week with 3 J/cm2 sq cm of combined 660 and 890 nm light; wounds in the other groups were not irradiated. Wounds were evaluated with digital photography and image analysis, either on day 7 or day 14, with biopsies obtained on day 14 for histological studies.<br />Results: Undernourishment retarded the mean healing rate of the undernourished sham wounds (p < 0.01), but not the undernourished Light emission diode treated wounds, which healed significantly faster (p < 0.001) and as fast as the two nourished groups. Histological analysis showed a smaller percentage of collagen in the undernourished sham group compared with the three other groups, thus confirming our photographic image analysis data.<br />Conclusion: Phototherapy reverses the adverse healing effects of undernourishment. Similar beneficial effects may be achieved in patients with poor nutritional status.
- Subjects :
- Animals
Biopsy
Collagen analysis
Collagen radiation effects
Dose-Response Relationship, Radiation
Male
Nutritional Status
Rats, Wistar
Reproducibility of Results
Serum Albumin analysis
Skin Ulcer pathology
Skin Ulcer radiotherapy
Time Factors
Treatment Outcome
Lasers, Semiconductor therapeutic use
Low-Level Light Therapy methods
Skin pathology
Skin radiation effects
Wound Healing radiation effects
Subjects
Details
- Language :
- English
- ISSN :
- 1806-4841
- Volume :
- 89
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Anais brasileiros de dermatologia
- Publication Type :
- Academic Journal
- Accession number :
- 25387494
- Full Text :
- https://doi.org/10.1590/abd1806-4841.20143356