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The role of endoplasmic reticulum stress in human pathology.
- Source :
-
Annual review of pathology [Annu Rev Pathol] 2015; Vol. 10, pp. 173-94. Date of Electronic Publication: 2014 Oct 27. - Publication Year :
- 2015
-
Abstract
- Numerous genetic and environmental insults impede the ability of cells to properly fold and posttranslationally modify secretory and transmembrane proteins in the endoplasmic reticulum (ER), leading to a buildup of misfolded proteins in this organelle--a condition called ER stress. ER-stressed cells must rapidly restore protein-folding capacity to match protein-folding demand if they are to survive. In the presence of high levels of misfolded proteins in the ER, an intracellular signaling pathway called the unfolded protein response (UPR) induces a set of transcriptional and translational events that restore ER homeostasis. However, if ER stress persists chronically at high levels, a terminal UPR program ensures that cells commit to self-destruction. Chronic ER stress and defects in UPR signaling are emerging as key contributors to a growing list of human diseases, including diabetes, neurodegeneration, and cancer. Hence, there is much interest in targeting components of the UPR as a therapeutic strategy to combat these ER stress-associated pathologies.
Details
- Language :
- English
- ISSN :
- 1553-4014
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- Annual review of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25387057
- Full Text :
- https://doi.org/10.1146/annurev-pathol-012513-104649