Reduced polymorphism in the Kelch propeller domain in Plasmodium vivax isolates from Cambodia.

Authors :: Popovici J
Kao S
Eal L
Bin S
Kim S
Ménard D
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Jan; Vol. 59 (1), pp. 730-3. Date of Electronic Publication: 2014 Nov 10.
Publication Year :: 2015
Abstract: Polymorphism in the ortholog gene of the Plasmodium falciparum K13 gene was investigated in Plasmodium vivax isolates collected in Cambodia. All of them were Sal-1 wild-type alleles except two (2/284, 0.7%), and P. vivax K12 polymorphism was reduced compared to that of the P. falciparum K13 gene. Both mutant allele isolates had the same nonsynonymous mutation at codon 552 (V552I) and were from Ratanak Kiri province. These preliminary data should encourage additional studies for associating artemisinin or chloroquine resistance and K12 polymorphism.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

Subjects :: Antimanic Agents therapeutic use
Cambodia epidemiology
Drug Resistance genetics
Humans
Malaria, Vivax drug therapy
Malaria, Vivax epidemiology
Polymorphism, Genetic
Sequence Alignment
Genes, Protozoan genetics
Malaria, Vivax microbiology
Plasmodium vivax genetics

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