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An enantioselective total synthesis of Sch-725674.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2015 Jan 07; Vol. 13 (1), pp. 234-40. - Publication Year :
- 2015
-
Abstract
- An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the upper and lower fragments of the molecule, whereas cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction are used as key steps to complete the total synthesis.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25379975
- Full Text :
- https://doi.org/10.1039/c4ob02136c