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Preclinical evaluation of the immunomodulatory lymphocyte trafficking drug FTY720 for HIV prevention in the female genital mucosa of macaques.
- Source :
-
Journal of medical primatology [J Med Primatol] 2014 Oct; Vol. 43 (5), pp. 370-3. - Publication Year :
- 2014
-
Abstract
- FTY720 has been shown to reduce inflammatory cytokines and immune cells in the genital mucosa of macaques. This pilot study examined the ability of FTY720 to inhibit HIV acquisition. Systemic treatment with FTY720 failed to prevent or delay vaginal SHIV transmission.
- Subjects :
- Administration, Intravaginal
Administration, Intravenous
Animals
Cervix Uteri chemistry
Drug Evaluation, Preclinical
Female
Fingolimod Hydrochloride
HIV Infections prevention & control
Immunomodulation
Lymphocytes drug effects
Mucous Membrane chemistry
Mucous Membrane immunology
Pilot Projects
Simian Acquired Immunodeficiency Syndrome prevention & control
Sphingosine pharmacology
Vagina chemistry
Cervix Uteri immunology
Immunosuppressive Agents pharmacology
Macaca nemestrina
Propylene Glycols pharmacology
Simian Immunodeficiency Virus drug effects
Sphingosine analogs & derivatives
Vagina immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0684
- Volume :
- 43
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of medical primatology
- Publication Type :
- Academic Journal
- Accession number :
- 25379595
- Full Text :
- https://doi.org/10.1111/jmp.12120