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Bone mineral density at diagnosis of celiac disease and after 1 year of gluten-free diet.

Authors :
Pantaleoni S
Luchino M
Adriani A
Pellicano R
Stradella D
Ribaldone DG
Sapone N
Isaia GC
Di Stefano M
Astegiano M
Source :
TheScientificWorldJournal [ScientificWorldJournal] 2014; Vol. 2014, pp. 173082. Date of Electronic Publication: 2014 Oct 14.
Publication Year :
2014

Abstract

Atypical or silent celiac disease may go undiagnosed for many years and can frequently lead to loss of bone mineral density, with evolution to osteopenia or osteoporosis. The prevalence of the latter conditions, in case of new diagnosis of celiac disease, has been evaluated in many studies but, due to the variability of epidemiologic data and patient features, the results are contradictory. The aim of this study was to evaluate bone mineral density by dual-energy X-ray absorptiometry in 175 consecutive celiac patients at time of diagnosis (169 per-protocol, 23 males, 146 females; average age 38.9 years). Dual-energy X-ray absorptiometry was repeated after 1 year of gluten-free diet in those with T-score value <-1 at diagnosis. Stratification of patients according to sex and age showed a higher prevalence of low bone mineral density in men older than 30 years and in women of all ages. A 1-year gluten-free diet led to a significant improvement in lumbar spine and femoral neck mean T-score value. We propose that dual-energy X-ray absorptiometry should be performed at diagnosis of celiac disease in all women and in male aged >30 years, taking into account each risk factor in single patients.

Details

Language :
English
ISSN :
1537-744X
Volume :
2014
Database :
MEDLINE
Journal :
TheScientificWorldJournal
Publication Type :
Academic Journal
Accession number :
25379519
Full Text :
https://doi.org/10.1155/2014/173082