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Bone mineral density at diagnosis of celiac disease and after 1 year of gluten-free diet.
- Source :
-
TheScientificWorldJournal [ScientificWorldJournal] 2014; Vol. 2014, pp. 173082. Date of Electronic Publication: 2014 Oct 14. - Publication Year :
- 2014
-
Abstract
- Atypical or silent celiac disease may go undiagnosed for many years and can frequently lead to loss of bone mineral density, with evolution to osteopenia or osteoporosis. The prevalence of the latter conditions, in case of new diagnosis of celiac disease, has been evaluated in many studies but, due to the variability of epidemiologic data and patient features, the results are contradictory. The aim of this study was to evaluate bone mineral density by dual-energy X-ray absorptiometry in 175 consecutive celiac patients at time of diagnosis (169 per-protocol, 23 males, 146 females; average age 38.9 years). Dual-energy X-ray absorptiometry was repeated after 1 year of gluten-free diet in those with T-score value <-1 at diagnosis. Stratification of patients according to sex and age showed a higher prevalence of low bone mineral density in men older than 30 years and in women of all ages. A 1-year gluten-free diet led to a significant improvement in lumbar spine and femoral neck mean T-score value. We propose that dual-energy X-ray absorptiometry should be performed at diagnosis of celiac disease in all women and in male aged >30 years, taking into account each risk factor in single patients.
- Subjects :
- Absorptiometry, Photon
Adult
Bone Diseases, Metabolic diagnostic imaging
Bone Diseases, Metabolic etiology
Bone Diseases, Metabolic pathology
Celiac Disease complications
Celiac Disease diagnostic imaging
Celiac Disease pathology
Female
Femur Neck diagnostic imaging
Femur Neck pathology
Humans
Lumbar Vertebrae diagnostic imaging
Lumbar Vertebrae pathology
Male
Middle Aged
Osteoporosis diagnostic imaging
Osteoporosis etiology
Osteoporosis pathology
Risk Factors
Bone Density
Bone Diseases, Metabolic prevention & control
Celiac Disease diet therapy
Diet, Gluten-Free
Osteoporosis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1537-744X
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- TheScientificWorldJournal
- Publication Type :
- Academic Journal
- Accession number :
- 25379519
- Full Text :
- https://doi.org/10.1155/2014/173082