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IL2-IL21 gene cluster polymorphism is not associated with allograft function after kidney transplantation.
- Source :
-
International urology and nephrology [Int Urol Nephrol] 2014 Dec; Vol. 46 (12), pp. 2415-20. Date of Electronic Publication: 2014 Nov 08. - Publication Year :
- 2014
-
Abstract
- Background: Cytokines are key mediators of the immune response after transplantation. The interleukin (IL)-2 cytokine family, which includes IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, is of particular interest because of its importance in the allogenic response. The aim of this study was to examine the association between the rs6822844 gene polymorphism in the IL2-IL21 region and allograft function after kidney transplantation.<br />Methods: The study enrolled 270 Caucasian kidney allograft recipients (166 males and 104 females, mean age 47.63 ± 12.96 years). Following parameters were recorded in each case: recipient's age, delayed graft function (DGF), occurrence and number of episodes of acute rejection (AR), and chronic allograft dysfunction (CAD). Genotyping of the rs6822844 IL2-IL21 cluster gene polymorphism was performed using real-time PCR assay.<br />Results: There were no statistically significant differences in the genotypes and alleles of the rs6822844 IL2-IL21 cluster gene polymorphism among patients with DGF (p = 0.72), AR (p = 0.69) and CAD (p = 0.77), or in creatinine concentrations 1, 3, 6, 12, 24 or 36 months after transplantation (p = 0.46, p = 0.58, p = 0.6, p = 0.72, p = 0.7, p = 0.76, respectively).<br />Conclusion: It seems that the rs6822844 IL2-IL21 gene cluster polymorphism is of little importance in allograft function after kidney transplantation.
- Subjects :
- Alleles
Allografts
Delayed Graft Function immunology
Female
Genotype
Graft Rejection immunology
Humans
Interleukin-2 immunology
Interleukins immunology
Male
Middle Aged
Polymorphism, Genetic
Real-Time Polymerase Chain Reaction
Delayed Graft Function genetics
Graft Rejection genetics
Interleukin-2 genetics
Interleukins genetics
Kidney Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2584
- Volume :
- 46
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International urology and nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 25377634
- Full Text :
- https://doi.org/10.1007/s11255-014-0867-y