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Assessment of toxic effects of the methanol extract of Citrus macroptera Montr. Fruit via biochemical and hematological evaluation in female Sprague-Dawley rats.
- Source :
-
PloS one [PLoS One] 2014 Nov 04; Vol. 9 (11), pp. e111101. Date of Electronic Publication: 2014 Nov 04 (Print Publication: 2014). - Publication Year :
- 2014
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Abstract
- Citrus macroptera Montr. (C. macroptera) is locally known as Satkara. The fruit of this plant is used as appetite stimulant and in the treatment of fever. This study therefore aimed to evaluate the toxic effects of the fruit extract using some biochemical and hematological parameters in rat model. The effects of methanol extract of Citrus macroptera Montr. fruit administered at 250, 500 and 1000 mg/kg body weight were investigated on hematological and biochemical parameters in Sprague-Dawley female rats. Moreover, histopathological study was performed to observe the presence of pathological lesions in primary body organs. The extract presented no significant effect on body weight, percent water content, relative organ weight and hematological parameters in rat. Significant decrease from control group was observed in the levels of triglyceride, total cholesterol, low density lipoprotein and very low density lipoprotein; thus leading to significant decrease of cardiac risk ratio, castelli's risk index-2, atherogenic coefficient and atherogenic index of plasma at all doses. 500 mg/kg dose significantly decreased alkaline phosphatase (P<0.05), 1000 mg/kg dose significantly increased high density lipoprotein cholesterol (P<0.05) and 250 mg/kg dose significantly decreased the level of glycated hemoglobin (P<0.05) from the control group. There were no significant alterations observed with other serum biochemical parameters. Histopathological study confirmed the absence of inflammatory and necrotic features in the primary body organs. Study results indicate that methanolic fruit extract is unlikely to have significant toxicity. Moreover, these findings justified the cardio-protective, moderate hepato-protective and glucose controlling activities of the fruit extract.
- Subjects :
- Alkaline Phosphatase blood
Animals
Cholesterol blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Citrus metabolism
Female
Fruit chemistry
Fruit metabolism
Kidney pathology
Liver pathology
Lung pathology
Methanol chemistry
Myocardium pathology
Organ Size drug effects
Plant Extracts chemistry
Rats
Rats, Sprague-Dawley
Triglycerides blood
Body Weight drug effects
Citrus chemistry
Plant Extracts toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25369061
- Full Text :
- https://doi.org/10.1371/journal.pone.0111101