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Rhodium-catalyzed enantioselective hydrogenation of tetrasubstituted α-acetoxy β-enamido esters: a new approach to chiral α-hydroxyl-β-amino acid derivatives.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2014 Nov 19; Vol. 136 (46), pp. 16120-3. Date of Electronic Publication: 2014 Nov 05. - Publication Year :
- 2014
-
Abstract
- Asymmetric hydrogenation of tetrasubtitued α-acetoxy β-enamido esters with rhodium catalysts based on chiral diphosphine ligands provides an efficient and concise route to the synthesis of chiral α-hydroxyl-β-amino acid derivatives in excellent enantioselectivities. The products are valuable chiral building blocks in many biologically active compounds and have important applications in organic synthesis.
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 136
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 25354308
- Full Text :
- https://doi.org/10.1021/ja509005e