Back to Search
Start Over
Expression of soluble triggering receptor expressed on myeloid cells-1 in childhood CF and non-CF bronchiectasis.
- Source :
-
Pediatric pulmonology [Pediatr Pulmonol] 2015 Apr; Vol. 50 (4), pp. 333-9. Date of Electronic Publication: 2014 Oct 27. - Publication Year :
- 2015
-
Abstract
- Background: Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is demonstrating promise as an inflammatory biomarker of acute infection in various pulmonary conditions; including community acquired pneumonia, ventilator associated pneumonia and non-tuberculous mycobacterial infection.<br />Introduction: The expression of sTREM-1 has been poorly studied in all forms of bronchiectasis, both in the context of cystic fibrosis (CF) and non-cystic fibrosis bronchiectasis.<br />Method: Induced sputum samples were collected for sTREM-1 determination in children with HIV-associated bronchiectasis and CF-bronchiectasis. The presence or absence of an exacerbation was noted at study entry. Lung function parameters (FEV1, FVC, FEV1 /FVC, FEF(25-75)) were measured using the Viasys SpiroPro Jaeger Spirometer (Hoechberg, Germany).<br />Result: A total of twenty-six children with HIV-associated bronchiectasis and seventeen with CF were included. With respect to sTREM-1, the levels were readily detected in both groups, but were significantly higher in children with HIV-associated bronchiectasis (1244.0 pg/ml (iqr 194.5; 3755.3 pg/ml) and 204.9 pg/ml (iqr 66.9; 653.6 pg/ml) P = 0.003. There was a positive correlation between sTREM-1 and IL-8 as well as sputum neutrophil elastase in the HIV-bronchiectasis group (r = 0.715 and r = 0.630), respectively both P < 0.005. sTREM-1 was not further increased in subjects presenting with an acute pulmonary exacerbation in the HIV-associated bronchiectasis and in CF participants (P = 0.971 and P = 0.481), respectively. In the CF group sTREM-1 strongly correlated with FVC% predicted and FEV1 % predicted (r = 0.950 and r = 0.954), both P < 0.005.<br />Conclusion: The pulmonary innate immune functions are over-active in HIV-associated bronchiectasis, with readily detected sTREM-1 values, which were higher than those in CF. sTREM-1 does not correlate with markers of HIV-disease activity but does correlate with markers of neutrophilic inflammation. In CF sTREM-1 has a negative correlation with pulmonary function parameters.<br /> (© 2015 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Biomarkers metabolism
Child
Female
HIV Infections metabolism
Humans
Interleukin-8 metabolism
Leukocyte Elastase metabolism
Sputum metabolism
Triggering Receptor Expressed on Myeloid Cells-1
Bronchiectasis metabolism
Cystic Fibrosis metabolism
Membrane Glycoproteins metabolism
Receptors, Immunologic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1099-0496
- Volume :
- 50
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pediatric pulmonology
- Publication Type :
- Academic Journal
- Accession number :
- 25348906
- Full Text :
- https://doi.org/10.1002/ppul.23121