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RNF43 is frequently mutated in colorectal and endometrial cancers.
- Source :
-
Nature genetics [Nat Genet] 2014 Dec; Vol. 46 (12), pp. 1264-6. Date of Electronic Publication: 2014 Oct 26. - Publication Year :
- 2014
-
Abstract
- We report somatic mutations of RNF43 in over 18% of colorectal adenocarcinomas and endometrial carcinomas. RNF43 encodes an E3 ubiquitin ligase that negatively regulates Wnt signaling. Truncating mutations of RNF43 are more prevalent in microsatellite-unstable tumors and show mutual exclusivity with inactivating APC mutations in colorectal adenocarcinomas. These results indicate that RNF43 is one of the most commonly mutated genes in colorectal and endometrial cancers.
- Subjects :
- Adenomatous Polyposis Coli Protein genetics
Exome
Female
Gene Expression Regulation, Neoplastic
Humans
Microsatellite Repeats genetics
Phenotype
Sequence Analysis, DNA
Signal Transduction
Ubiquitin-Protein Ligases
Adenocarcinoma genetics
Colorectal Neoplasms genetics
DNA-Binding Proteins genetics
Endometrial Neoplasms genetics
Mutation
Oncogene Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 46
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 25344691
- Full Text :
- https://doi.org/10.1038/ng.3127