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Pulmonary hypertensive vascular changes in lungs of patients with sudden unexpected death. Emphasis on congenital heart disease, Eisenmenger syndrome, postoperative deaths and death during pregnancy and postpartum.
- Source :
-
Journal of clinical pathology [J Clin Pathol] 2015 Jan; Vol. 68 (1), pp. 18-21. Date of Electronic Publication: 2014 Oct 23. - Publication Year :
- 2015
-
Abstract
- Aims: Pulmonary hypertension (PH) in asymptomatic patients is a rare cause of sudden death. This study aims to determine the incidence of this entity and raise awareness among pathologists.<br />Methods: We retrospectively investigated 44 cases of sudden unexpected death in relation to PH in patients not on antihypertensive therapy. This is the largest pathological study reported.<br />Results: We report 44 cases of sudden death due to PH in which 28 (63.63%) were female and 16 (36.36%) were male, and the age range was from 5 days to 93 years old (mean age: 24±20). The majority had no clinical evidence of PH prior to death with none on therapy. The majority died at rest, 18 cases (40.90%), while 7 patients (15.90%) died following cardiac surgery and 7 patients (15.90%) during pregnancy or postpartum, 6 of whom had congenital heart disease. The cause of PH was recognised as congenital heart disease in 27 patients (61.36%), 14 of whom had simple congenital heart disease, such as atrial or ventricular septal defect,and 13 had complex congenital heart disease with associated atrial septal defect or ventricular septal defect. The remaining 17 patients (29.55%) suffered from primary PH due to plexiform arteriopathy, veno-occlusive disease and thromboembolic disease. Extensive sampling of the lungs is required to detect the lesions microscopically in these conditions.<br />Conclusions: It is important that clinicians and pathologists be aware of the risk of sudden unexpected death in asymptomatic patients with PH, especially in those with congenital heart disease, after cardiac surgery or pregnancy.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Eisenmenger Complex complications
Female
Heart Defects, Congenital complications
Humans
Hypertension, Pulmonary pathology
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Postoperative Complications
Postpartum Period
Pregnancy
Retrospective Studies
Young Adult
Death, Sudden etiology
Hypertension, Pulmonary complications
Hypertension, Pulmonary epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1472-4146
- Volume :
- 68
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 25342758
- Full Text :
- https://doi.org/10.1136/jclinpath-2014-202613