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Sulfonamide-bridged nucleic acid: synthesis, high RNA selective hybridization, and high nuclease resistance.
- Source :
-
Organic letters [Org Lett] 2014 Nov 07; Vol. 16 (21), pp. 5640-3. Date of Electronic Publication: 2014 Oct 24. - Publication Year :
- 2014
-
Abstract
- 2'-N,4'-C-(N-methylamino)sulfonylmethylene-bridged thymidine (SuNA), which has a six-membered linkage including a sulfonamide moiety, was synthesized and introduced into oligonucleotides. The oligonucleotides containing SuNA exhibited excellent nuclease resistance, a high affinity toward single-stranded RNA, and a low affinity toward single-stranded DNA compared to the natural oligonucleotide.
- Subjects :
- Bridged-Ring Compounds chemistry
Molecular Structure
Nucleic Acid Hybridization
Sulfonamides chemical synthesis
Thymidine chemistry
Bridged-Ring Compounds chemical synthesis
Nucleic Acids chemistry
Oligonucleotides chemistry
RNA chemistry
Ribonucleases chemical synthesis
Ribonucleases chemistry
Sulfonamides chemistry
Thymidine analogs & derivatives
Thymidine chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 25341881
- Full Text :
- https://doi.org/10.1021/ol503029v