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Spread of Streptococcus pneumoniae serotype 8-ST63 multidrug-resistant recombinant Clone, Spain.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2014 Nov; Vol. 20 (11), pp. 1848-56. - Publication Year :
- 2014
-
Abstract
- Since 2004, a total of 131 isolates of Streptococcus pneumoniae multidrug-resistant invasive serotype 8 have been detected in Spain. These isolates showed resistance to erythromycin, clindamycin, tetracycline, and ciprofloxacin. All isolates were obtained from adult patients and shared a common genotype (sequence type [ST]63; penicillin-binding protein 1a [pbp1a], pbp2b, and pbp2x gene profiles; ermB and tetM genes; and a ParC-S79F change). Sixty-eight isolates that required a ciprofloxacin MIC ≥16 μg/mL had additional gyrA gene changes. Serotype 8-ST63 pbp2x sequences were identical with those of antimicrobial drug-susceptible serotype 8-ST53 isolates. Serotype 8-ST63 pbp2b sequences were identical with those of the multidrug-resistant Sweden 15A-ST63 clone. Recombination between the capsular locus and flanking regions of an ST53 isolate (donor) and an ST63 pneumococcus (recipient) generated the novel 15A-ST63 clone. One recombination point was upstream of pbp2x and another was within pbp1a. A serotype 8-ST63 clone was identified as a cause of invasive disease in Spain.
- Subjects :
- Adolescent
Adult
Amino Acid Sequence
Anti-Bacterial Agents pharmacology
Bacterial Proteins chemistry
Bacterial Proteins genetics
Base Sequence
Child
Codon
Gene Order
Genome, Bacterial
Genotype
Humans
Microbial Sensitivity Tests
Molecular Sequence Data
Molecular Typing
Phenotype
Polymorphism, Genetic
Serogroup
Spain epidemiology
Streptococcus pneumoniae genetics
Young Adult
Drug Resistance, Multiple, Bacterial genetics
Pneumococcal Infections epidemiology
Pneumococcal Infections microbiology
Recombination, Genetic
Streptococcus pneumoniae classification
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 20
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 25340616
- Full Text :
- https://doi.org/10.3201/eid2011.131215