A new [2H]-labelled α-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates.

Authors :: Heinkele G
Geditz MC
Ganchev B
Kerb R
Hofmann U
Mürdter TE
Source :: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2014 Oct; Vol. 57 (12), pp. 699-703. Date of Electronic Publication: 2014 Oct 22.
Publication Year :: 2014
Abstract: A new reaction pathway for the synthesis of a [(2)H]-labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope-labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis.<br /> (Copyright © 2014 John Wiley & Sons, Ltd.)

Subjects :: Chemistry Techniques, Synthetic methods
Acetamides chemical synthesis
Chloroacetates chemical synthesis
Deuterium chemistry
Glucuronides chemical synthesis
Radiopharmaceuticals chemical synthesis

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