Back to Search
Start Over
Expanding the indications of pancreas transplantation alone.
- Source :
-
Pancreas [Pancreas] 2014 Nov; Vol. 43 (8), pp. 1190-3. - Publication Year :
- 2014
-
Abstract
- Objectives: Total pancreatectomy (TP) is associated with postoperative endocrine and exocrine insufficiency. Especially, insulin therapy reduces quality of life and may lead to long-term complications. We review the literature with regard to the potential option of pancreas transplantation alone (PTA) after TP in patients with chronic pancreatitis or benign tumors.<br />Methods: A MEDLINE search (1958-2013) using the terminologies pancreas transplantation, pancreas transplantation alone, total pancreatectomy, morbidity, mortality, insulin therapy, and quality of life was performed. In addition, the current book and congress publications were reviewed.<br />Results: Total pancreatectomy after benign and borderline tumors as well as chronic pancreatitis is continuously increasing. Despite improvement of exogenous insulin therapy, more than 50% of these patients experience severe glucose control problems, which cause up to 50% long-term mortality. Pancreas transplantation alone can cure both endocrine and exocrine insufficiency and reduce the associated risks. The 3-year graft and patient survival rates after PTA are up to 73% and 100%, respectively.<br />Conclusions: Pancreas transplantation alone after TP in patients with pancreatitis or benign tumors improves the recipient's quality of life and reduces long-term mortality. Considering the amount of available organs and potential candidates, PTA can be a treatment option for patients after TP with chronic pancreatitis or benign tumors.
- Subjects :
- Cost-Benefit Analysis
Diabetes Mellitus, Type 1 drug therapy
Diabetes Mellitus, Type 1 economics
Diabetes Mellitus, Type 1 etiology
Diabetes Mellitus, Type 1 surgery
Exocrine Pancreatic Insufficiency etiology
Exocrine Pancreatic Insufficiency surgery
Global Health
Graft Survival
Humans
Immunosuppressive Agents adverse effects
Immunosuppressive Agents therapeutic use
Insulin economics
Insulin therapeutic use
Islets of Langerhans Transplantation economics
Pancreatectomy adverse effects
Pancreatic Neoplasms surgery
Pancreatitis, Chronic surgery
Postoperative Complications economics
Postoperative Complications mortality
Postoperative Complications psychology
Postoperative Complications surgery
Quality of Life
Tissue and Organ Procurement
Treatment Outcome
Waiting Lists
Pancreas Transplantation economics
Pancreas Transplantation methods
Pancreas Transplantation statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 25333402
- Full Text :
- https://doi.org/10.1097/MPA.0000000000000181