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(18)F-fluorodeoxyglucose-positron emission tomography/computed tomography after one cycle of chemotherapy in patients with diffuse large B-cell lymphoma: results of a Nordic/US intergroup study.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2015 Jul; Vol. 56 (7), pp. 2005-12. Date of Electronic Publication: 2014 Nov 20. - Publication Year :
- 2015
-
Abstract
- We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to International Harmonization Project criteria (IHP), Deauville 5-point scale (D 5PS) with scores 1-3 considered negative (D 5PS > 3) and D 5PS with scores 1-4 considered negative (D 5PS = 5). Ratios of tumor maximum standardized uptake value (SUVmax) to liver SUVmax were also analyzed. We found no difference in progression-free survival (PFS) between PET-negative and PET-positive patients according to IHP and D 5PS > 3. The 2-year PFS using D 5PS = 5 was 50.9% in the PET-positive group and 84.8% in the PET-negative group (p = 0.002). A tumor/liver SUVmax cut-off of 3.1 to distinguish D 5PS scores of 4 and 5 provided the best prognostic value. PET after one course of chemotherapy was not able to safely discriminate PET-positive and PET-negative patients in different prognostic groups.
- Subjects :
- Adult
Aged
Aged, 80 and over
Denmark
Female
Finland
Follow-Up Studies
Humans
Lymphoma, Large B-Cell, Diffuse drug therapy
Lymphoma, Large B-Cell, Diffuse mortality
Male
Middle Aged
Multimodal Imaging
Neoplasm Staging
Norway
Prognosis
Prospective Studies
Survival Rate
Sweden
Tissue Distribution
United States
Young Adult
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Fluorodeoxyglucose F18 pharmacokinetics
Lymphoma, Large B-Cell, Diffuse pathology
Positron-Emission Tomography methods
Radiopharmaceuticals pharmacokinetics
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 56
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 25330442
- Full Text :
- https://doi.org/10.3109/10428194.2014.975800