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Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting.
- Source :
-
Interactive cardiovascular and thoracic surgery [Interact Cardiovasc Thorac Surg] 2015 Jan; Vol. 20 (1), pp. 68-73. Date of Electronic Publication: 2014 Oct 16. - Publication Year :
- 2015
-
Abstract
- Objectives: Objective evaluation of the impact of minimized extracorporeal circulation (MECC) on perioperative cognitive brain function in coronary artery bypass grafting (CABG) by electroencephalogram P300 wave event-related potentials and number connection test (NCT) as metrics of cognitive function.<br />Methods: Cognitive brain function was assessed in 31 patients in 2013 with a mean age of 65 years [standard deviation (SD) 10] undergoing CABG by the use of MECC with P300 auditory evoked potentials (peak latencies in milliseconds) directly prior to intervention, 7 days after and 3 months later. Number connection test, serving as method of control, was performed simultaneously in all patients.<br />Results: Seven days following CABG, cognitive P300 evoked potentials were comparable with preoperative baseline values [vertex (Cz) 376 (SD 11) ms vs 378 (18) ms, P = 0.39; frontal (Fz) 377 (11) vs 379 (21) ms, P = 0.53]. Cognitive brain function at 3 months was compared with baseline values [(Cz) 376 (11) ms vs 371 (14 ms) P = 0.09; (Fz) 377 (11) ms vs 371 (15) ms, P = 0.04]. Between the first postoperative measurement and 3 months later, significant improvement was observed [(Cz) 378 (18) ms vs 371 (14) ms, P = 0.03; (Fz) 379 (21) vs 371 (15) ms, P = 0.02]. Similar clearly corresponding patterns could be obtained via the number connection test. Results could be confirmed in repeated measures analysis of variance for Cz (P = 0.05) and (Fz) results (P = 0.04).<br />Conclusions: MECC does not adversely affect cognitive brain function after CABG. Additionally, these patients experience a substantial significant cognitive improvement after 3 months, evidentiary proving that the concept of MECC ensures safety and outcome in terms of brain function.<br /> (© The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)
- Subjects :
- Aged
Cognition Disorders diagnosis
Cognition Disorders etiology
Cognition Disorders physiopathology
Cognition Disorders psychology
Electroencephalography
Event-Related Potentials, P300
Extracorporeal Circulation adverse effects
Female
Humans
Male
Middle Aged
Neuropsychological Tests
Predictive Value of Tests
Prospective Studies
Reaction Time
Recovery of Function
Risk Factors
Time Factors
Treatment Outcome
Brain physiopathology
Cognition
Cognition Disorders prevention & control
Coronary Artery Bypass adverse effects
Extracorporeal Circulation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1569-9285
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Interactive cardiovascular and thoracic surgery
- Publication Type :
- Academic Journal
- Accession number :
- 25323401
- Full Text :
- https://doi.org/10.1093/icvts/ivu341