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Listeria monocytogenes-associated biliary tract infections: a study of 12 consecutive cases and review.
- Source :
-
Medicine [Medicine (Baltimore)] 2014 Oct; Vol. 93 (18), pp. e105. - Publication Year :
- 2014
-
Abstract
- At present, little is known regarding Listeria monocytogenes-associated biliary tract infection, a rare form of listeriosis.In this article, we will study 12 culture-proven cases reported to the French National Reference Center for Listeria from 1996 to 2013 and review the 8 previously published cases.Twenty cases were studied: 17 cholecystitis, 2 cholangitis, and 1 biliary cyst infection. Half were men with a median age of 69 years (32-85). Comorbidities were present in 80%, including cirrhosis, rheumatoid arthritis, and diabetes. Five patients received immunosuppressive therapy, including corticosteroids and anti-tumor necrosis factor biotherapies. Half were afebrile. Blood cultures were positive in 60% (3/5). Gallbladder histological lesions were analyzed in 3 patients and evidenced acute, chronic, or necrotic exacerbation of chronic infection. Genoserogroup of the 12 available strains were IVb (n=6), IIb (n=5), and IIa (n=1). Their survival in the bile was not enhanced when compared with isolates from other listeriosis cases. Adverse outcome was reported in 33% (5/15): 3 deaths, 1 recurrence; 75% of the patients with adverse outcome received inadequate antimicrobial therapy (P=0.033).Biliary tract listeriosis is a severe infection associated with high mortality in patients not treated with appropriate therapy. This study provides medical relevance to in vitro and animal studies that had shown Listeria monocytogenes ability to survive in bile and induce overt biliary infections.
- Subjects :
- Abdominal Pain epidemiology
Abdominal Pain microbiology
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents therapeutic use
Bacteremia diagnosis
Bacteremia drug therapy
Bacteremia epidemiology
Biliary Tract Diseases drug therapy
Biliary Tract Diseases epidemiology
Cholangitis drug therapy
Cholangitis epidemiology
Cholecystectomy statistics & numerical data
Cholecystitis drug therapy
Cholecystitis epidemiology
Cholecystolithiasis epidemiology
Comorbidity
Cysts drug therapy
Cysts epidemiology
Drug Resistance, Bacterial
Female
Fever epidemiology
Fever microbiology
France epidemiology
Gallbladder Diseases epidemiology
Gallbladder Diseases microbiology
Humans
Immunosuppressive Agents adverse effects
Listeria monocytogenes genetics
Listeriosis drug therapy
Male
Medication Errors
Middle Aged
Necrosis
Penicillins therapeutic use
Population Surveillance
Retrospective Studies
Biliary Tract Diseases microbiology
Cholangitis microbiology
Cholecystitis microbiology
Cysts microbiology
Listeriosis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 93
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25319439
- Full Text :
- https://doi.org/10.1097/MD.0000000000000105