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Timing of fat and liquid sugar intake alters substrate oxidation and food efficiency in male Wistar rats.
- Source :
-
Chronobiology international [Chronobiol Int] 2015 Mar; Vol. 32 (2), pp. 289-98. Date of Electronic Publication: 2014 Oct 15. - Publication Year :
- 2015
-
Abstract
- In addition to the amount of ingested calories, both timing of food intake and meal composition are determinants of body weight gain. However, at present, it is unknown if the inappropriate timing of diet components is responsible for body weight gain. In the present study, we therefore studied a time-dependent effect of the diet composition on energy homeostasis. Male Wistar rats were subjected to chow ad libitum (chow group) or a choice diet with saturated fat, a 30% sugar solution, chow and tap water. The choice diet was provided either with all components ad libitum (AL), with ad libitum access to chow, tap water and a 30% sugar solution, but with access to saturated fat only during the light period (LF), or with ad libitum access to chow, tap water and saturated fat, but access to a 30% sugar solution only during the light period (LS). Caloric intake and body weight gain were monitored during 31 days. Energy expenditure was measured in the third week in calorimetric cages. All rats on a choice diet showed hyperphagia and gained more body weight compared to the chow group. Within the choice diet groups, rats on the LS diet were most food efficient (i.e. gained most body weight per ingested calorie) and showed a lower respiratory exchange ratio (RER) with an anti-phasic pattern, whereas no differences in locomotor activity or heat production were found. Collectively these data indicate that the timing of the diet composition affects food efficiency, most likely due to a shifted oxidation pattern, which can predispose for obesity. Further studies are underway to assess putative mechanisms involved in this dysregulation.
- Subjects :
- Animals
Body Composition
Body Weight
Calorimetry
Circadian Rhythm
Diabetes Mellitus, Type 2 physiopathology
Diet
Disease Models, Animal
Energy Intake physiology
Homeostasis
Leptin blood
Male
Obesity physiopathology
Oxygen chemistry
Rats
Rats, Wistar
Time Factors
Weight Gain
Dietary Fats administration & dosage
Dietary Sucrose administration & dosage
Eating physiology
Feeding Behavior
Light
Subjects
Details
- Language :
- English
- ISSN :
- 1525-6073
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Chronobiology international
- Publication Type :
- Academic Journal
- Accession number :
- 25317718
- Full Text :
- https://doi.org/10.3109/07420528.2014.971177