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Prognostic value of cyclin B in endometrial endometrioid adenocarcinoma.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2015 Feb; Vol. 36 (2), pp. 953-7. Date of Electronic Publication: 2014 Oct 15. - Publication Year :
- 2015
-
Abstract
- Cyclins are a group of cell cycle regulatory proteins. Cyclin B acts as an activator to cyclin-dependent kinase 1 (CDK1), a protein kinase essential for G2/M phase transition. Deregulation of cyclins has been linked to a number of malignant neoplasms, but the impact on clinicopathological parameters seems to be cancer-specific. Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including breast and esophageal cancer, but its impact on endometrial cancer has not been extensively studied. For this study, 211 endometrial endometrioid adenocarcinoma samples were obtained from patients surgically treated at the Oulu University Hospital. The samples were immunohistochemically stained and analyzed for cyclin B expression. The relationships between cyclin B expression and conventional prognostic factors were analyzed. A discrimination threshold for survival analyses was calculated by utilizing the receiver operator characteristic (ROC) method. Cyclin B expression correlated with grade and advanced stage. Survival analyses showed that cyclin B expression affects cancer-specific survival in univariate analysis. In multivariate analysis, the results were indicative that cyclin B may hold independent prognostic significance, but further studies are required to assess this.
- Subjects :
- Adult
Aged
Aged, 80 and over
CDC2 Protein Kinase
Carcinoma, Endometrioid pathology
Cyclin-Dependent Kinases genetics
Female
G2 Phase Cell Cycle Checkpoints genetics
Gene Expression Regulation, Neoplastic
Humans
Middle Aged
Neoplasm Staging
Survival Analysis
Biomarkers, Tumor biosynthesis
Carcinoma, Endometrioid genetics
Cyclin B biosynthesis
Prognosis
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25315186
- Full Text :
- https://doi.org/10.1007/s13277-014-2676-4