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The risk of elevated prolactin levels in pediatric patients exposed to antipsychotics for the treatment of schizophrenia and schizophrenia spectrum disorders: protocol for a systematic review and meta-analysis.
- Source :
-
Systematic reviews [Syst Rev] 2014 Oct 13; Vol. 3, pp. 116. Date of Electronic Publication: 2014 Oct 13. - Publication Year :
- 2014
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Abstract
- Background: Antipsychotic medications, particularly second-generation antipsychotics, are increasingly being used to alleviate the symptoms of schizophrenia and other severe mental disorders in the pediatric population. While evidence-based approaches examining efficacy and safety outcomes have been reported, no review has evaluated prolactin-based adverse events for antipsychotic treatments in schizophrenia and schizophrenia spectrum disorders.<br />Methods/design: Searches involving MEDLINE, EMBASE, CENTRAL, PsycINFO, and clinical trial registries (ClinicalTrials.gov, Drug Industry Document Archive [DIDA], International Clinical Trials Registry Platform [ICTRP]) will be used to identify relevant studies. Two reviewers will independently screen abstracts and relevant full-text articles of the papers identified by the initial search according to the prospectively defined eligibility criteria. Data extraction will be conducted in duplicate independently. Pairwise random effects meta-analyses and network meta-analyses will be conducted on individual drug and class effects where appropriate.<br />Discussion: This systematic review will evaluate prolactin-based adverse events of first- and second-generation antipsychotics in the pediatric population with schizophrenia and schizophrenia spectrum disorders. It will also seek to strengthen the evidence base of the safety of antipsychotics by incorporating both randomized controlled trials and observational studies.<br />Systematic Review Registration: PROSPERO CRD42014009506.
- Subjects :
- Adolescent
Child
Child, Preschool
Female
Galactorrhea blood
Galactorrhea chemically induced
Gynecomastia blood
Gynecomastia chemically induced
Humans
Male
Menstruation Disturbances blood
Menstruation Disturbances chemically induced
Sexual Dysfunction, Physiological blood
Sexual Dysfunction, Physiological chemically induced
Systematic Reviews as Topic
Antipsychotic Agents adverse effects
Prolactin blood
Research Design
Schizophrenia blood
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2046-4053
- Volume :
- 3
- Database :
- MEDLINE
- Journal :
- Systematic reviews
- Publication Type :
- Academic Journal
- Accession number :
- 25312992
- Full Text :
- https://doi.org/10.1186/2046-4053-3-116