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Multicentric study on ¹⁸F-FDG-PET/CT breast incidental uptake in patients studied for non-breast malignant purposes.
- Source :
-
Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol] 2015 Jan-Feb; Vol. 34 (1), pp. 24-9. Date of Electronic Publication: 2014 Oct 11. - Publication Year :
- 2015
-
Abstract
- Aim: Our study has aimed to establish the prevalence and pathological nature of fluorine-18-fluorodeoxyglucose ((18)F-FDG) breast incidental uptake (BIU) in patients studied for non-malignant breast tumours and then to compare our data obtained in three Italian nuclear medicine centres with those available in literature.<br />Material and Methods: We retrospectively evaluated 42,927 (18)F-FDG-PET/CT scans performed on patients studied in three Italian Nuclear Medicine Centres. All patients underwent (18)F-FDG-PET/CT for oncologic purposes not related to breast disease.<br />Results: Among 42,927 scans, a BIU was identified in 79 (0.18%) patients, 75 (95%) female and 4 (5%) male with an average age of 62 ± 17 years. Twenty-five out of 35 (71.5%) BIUs were malignant and 10/35 (28.5%) benign. Among the 25/35 incidentalomas that were malignant, 12/25 (48%) were infiltrating ductal carcinoma, 5/25 (20%) ductal carcinoma (infiltrating and in situ), 4/25 (16%) lobular carcinoma, 2/25 (8%) ductal carcinoma in situ and 2/25 (8%) were metastases from the primary tumour under investigation. Of the 10 BIUs that were benign in the histological examination, after further investigations it was found that 9/10 (90%) were fibroadenomas and 1/10 (10%) was a benign lesion not better specified. The lesion to liver or to blood-pool SUVmax ratio in malignant lesions is significantly higher than in benign ones.<br />Conclusions: Our multicenter study demonstrates that, although they are uncommon, BIUs show a high percentage of malignancy and therefore requires further research.<br /> (Copyright © 2014 Elsevier España, S.L.U. and SEMNIM. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Breast Diseases diagnostic imaging
Breast Diseases epidemiology
Breast Neoplasms chemistry
Breast Neoplasms epidemiology
Breast Neoplasms secondary
Breast Neoplasms, Male diagnostic imaging
Breast Neoplasms, Male epidemiology
Carcinoma, Ductal, Breast chemistry
Carcinoma, Ductal, Breast epidemiology
Carcinoma, Intraductal, Noninfiltrating chemistry
Carcinoma, Intraductal, Noninfiltrating diagnostic imaging
Carcinoma, Intraductal, Noninfiltrating epidemiology
Carcinoma, Lobular chemistry
Carcinoma, Lobular epidemiology
Female
Fibroadenoma chemistry
Fibroadenoma epidemiology
Humans
Incidental Findings
Italy
Male
Middle Aged
Neoplasms, Multiple Primary chemistry
Neoplasms, Multiple Primary epidemiology
Retrospective Studies
Tissue Distribution
Breast Neoplasms diagnostic imaging
Carcinoma, Ductal, Breast diagnostic imaging
Carcinoma, Lobular diagnostic imaging
Fibroadenoma diagnostic imaging
Fluorine Radioisotopes pharmacokinetics
Fluorodeoxyglucose F18 pharmacokinetics
Neoplasms, Multiple Primary diagnostic imaging
Positron Emission Tomography Computed Tomography methods
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 2253-8070
- Volume :
- 34
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Revista espanola de medicina nuclear e imagen molecular
- Publication Type :
- Academic Journal
- Accession number :
- 25312053
- Full Text :
- https://doi.org/10.1016/j.remn.2014.08.003