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Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve.
- Source :
-
European journal of histochemistry : EJH [Eur J Histochem] 2014 Jul 18; Vol. 58 (3), pp. 2383. Date of Electronic Publication: 2014 Jul 18. - Publication Year :
- 2014
-
Abstract
- Ascending aortic aneurysm (AsAA) is a consequence of medial degeneration (MD), deriving from apoptotic loss of smooth muscle cells (SMC) and fragmentation of elastin and collagen fibers. Alterations of extracellular matrix structure and protein composition, typical of medial degeneration, can modulate intracellular pathways. In this study we examined the relevance of superoxide dismutase (SOD3) and Akt in AsAA pathogenesis, evaluating their tissue distribution and protein levels in ascending aortic tissues from controls (n=6), patients affected by AsAA associated to tricuspid aortic valve (TAV, n=9) or bicuspid aortic valve (BAV, n=9). The results showed a significant reduction of SOD3, phospho-Akt and Akt protein levels in AsAA tissues from patients with BAV, compared to controls, whereas the differences observed between controls and patients with TAV  were not significant. The decreased levels of SOD3 and Akt in BAV aortic tissues are associated with decreased Erk1/Erk2 phosphorylation and MMP-9 levels increase. The authors suggest a role of decreased SOD3 protein levels in the progression of AsAA with BAV and a link between ECM modifications of aortic media layer and impaired Erk1/Erk2 and Akt signaling in the late stages of the aortopathy associated with BAV.
- Subjects :
- Aged
Aorta pathology
Aortic Valve enzymology
Bicuspid Aortic Valve Disease
Female
Humans
Immunohistochemistry
Male
Reference Standards
Aortic Aneurysm enzymology
Aortic Aneurysm physiopathology
Aortic Valve abnormalities
Aortic Valve Insufficiency
Extracellular Space enzymology
Heart Valve Diseases enzymology
Proto-Oncogene Proteins c-akt metabolism
Superoxide Dismutase chemistry
Tricuspid Valve enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 2038-8306
- Volume :
- 58
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of histochemistry : EJH
- Publication Type :
- Academic Journal
- Accession number :
- 25308842
- Full Text :
- https://doi.org/10.4081/ejh.2014.2383