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Improved 5-year survival of patients with immunochemical faecal blood test-screen-detected colorectal cancer versus non-screening cancers in northern Italy.
- Source :
-
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2015 Jan; Vol. 47 (1), pp. 68-72. Date of Electronic Publication: 2014 Oct 08. - Publication Year :
- 2015
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Abstract
- Background: Colorectal cancer screening may reduce disease-related mortality by early-stage detection of cancers.<br />Aims: To study the effect of a single immunochemical faecal occult blood test (i-FOBt) screening round on reduction in colorectal cancer-related-mortality among average risk subjects.<br />Methods: Comparison of 5-year mortality rates in 3 cohorts from a Northern Italian province: (1) colorectal cancers detected at the 1st biennial round of a mass-screening programme targeting 50-69 years old subjects, (2) non-screening cancers symptomatically diagnosed during the same time period, and (3) cancers detected in the pre-screening biennium. Multivariate analyses were performed with the Cox regression model including tumour node metastasis (TNM) stage at diagnosis, anatomical distribution of cancers, age at diagnosis, gender and patient group. Kaplan-Meyer survival estimates and log-rank test for equality of survivor functions were calculated.<br />Results: Stage distribution significantly differed between screening and non-screening colorectal cancers: 73% of screen-detected colorectal cancers were stages I and II versus 43% and 40% of non-screening and pre-screening colorectal cancers. Cumulative 5-year mortality rate was significantly lower in screening compared to non-screening or pre-screening colorectal cancers patients (19% versus 37% and 41%, p < 0.001).<br />Conclusions: Colorectal cancers were detected at earlier stages in i-FOBT-positive subjects in comparison with non-screening patients; colorectal cancers found at screening had a significantly improved 5-year survival.<br /> (Copyright © 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
Carcinoma mortality
Carcinoma pathology
Cohort Studies
Colorectal Neoplasms mortality
Colorectal Neoplasms pathology
Female
Humans
Immunochemistry
Italy
Male
Middle Aged
Neoplasm Staging
Proportional Hazards Models
Carcinoma diagnosis
Colorectal Neoplasms diagnosis
Early Detection of Cancer
Occult Blood
Registries
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 47
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 25306524
- Full Text :
- https://doi.org/10.1016/j.dld.2014.09.015