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[Effect of long-term treatment with guanfacine on selected humoral metabolic indices in patients with primary hypertension].

Authors :
Knypl K
Wocial B
Chodakowska J
Brym E
Czerniewska E
Wacławek-Maczkowska J
Kuczyńska K
Berent H
Januszewicz W
Source :
Polski tygodnik lekarski (Warsaw, Poland : 1960) [Pol Tyg Lek] 1989 Mar 20-27; Vol. 44 (12-13), pp. 293-6.
Publication Year :
1989

Abstract

An effect of the treatment with guanfacine on the activity of the adreno-sympathetic system, beta-thromboglobulin, beta-endorphin, and blood lipids was studied in 30 patients with the primary arterial blood hypertension. It was found that guanfacine significantly decreases plasma noradrenaline, adrenaline, and dopamine. Moreover, it decreases the excretion of noradrenaline, adrenaline and 4-hydroxy-3-methoxy-phenylglycol. These effects correlate with the drop in both systolic and diastolic blood pressure. A decrease in plasma renin activity was also observed. It correlated with the blood pressure drops. Guanfacine increased beta-endorphin levels while beta-thromboglobulin, total cholesterol and triglycerides levels remained unaffected. The authors suggest that the hypotensive effect of guanfacine is related to the decrease in adreno-sympathetic system activity and plasma renin activity and no effect on the erythrocyte activity and lipids metabolism.

Details

Language :
Polish
ISSN :
0032-3756
Volume :
44
Issue :
12-13
Database :
MEDLINE
Journal :
Polski tygodnik lekarski (Warsaw, Poland : 1960)
Publication Type :
Academic Journal
Accession number :
2530502