The synthesis of 14C-labeled N-succinimidyl-3-maleimidopropionate, a linker molecule for PEGylated biologics.

Authors :: Cao K
Maxwell BD
Bonacorsi SJ
Source :: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2014 Oct; Vol. 57 (12), pp. 667-9. Date of Electronic Publication: 2014 Oct 10.
Publication Year :: 2014
Abstract: Carbon-14 labeled linker molecule, N-succinimidyl-3-maleimidopropionate was prepared for disposition studies of PEGylated biologics. Our new route started with 100 mCi of carbon-14 labeled Potassium cyanide (KCN) to prepare 55 mCi of [1-(14)C]N-succinimidyl-3-maleimidopropionate, 6 in five steps. This represents a multiple of 5.5× improvement in the yield of the desired labeled product compared with our previous synthesis.<br /> (Copyright © 2014 John Wiley & Sons, Ltd.)

Subjects :: Carbon Radioisotopes chemistry
Maleimides chemistry
Polyethylene Glycols chemistry
Radiopharmaceuticals chemistry
Succinimides chemistry
Maleimides chemical synthesis
Radiopharmaceuticals chemical synthesis
Succinimides chemical synthesis

Full Text Access

Tools