Palladium-catalyzed direct C-H functionalization of benzoquinone.

Authors :: Walker SE
Jordan-Hore JA
Johnson DG
Macgregor SA
Lee AL
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Dec 08; Vol. 53 (50), pp. 13876-9. Date of Electronic Publication: 2014 Oct 10.
Publication Year :: 2014
Abstract: A direct Pd-catalyzed C-H functionalization of benzoquinone (BQ) can be controlled to give either mono- or disubstituted BQ, including the installation of two different groups in a one-pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cycloalkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.<br /> (© 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.)