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[Molecular approaches to systemic therapy of adenoid cystic carcinoma of the head and neck area].
- Source :
-
Laryngo- rhino- otologie [Laryngorhinootologie] 2014 Oct; Vol. 93 (10), pp. 657-64. Date of Electronic Publication: 2014 Oct 10. - Publication Year :
- 2014
-
Abstract
- The adenoid cystic carcinoma (ACC) is a neurotropic salivary gland tumor with a high blood-borne metastasis tendency. The treatment of choice for localized disease consists of radical surgical resection and, depending on resection status, adjuvant radiotherapy. Due to the high recurrence rate with limited local therapeutic options and frequent occurrence of distant metastases, one is confronted inevitably with the search for an adequate systemic therapy. ACC shows little response to a variety of chemotherapeutic agents, partial or complete remissions are extremely rare. Beside classical chemotherapies, immunotherapeutics and targeted therapies with more favorable side effect profiles were tested in trials, but due to the small number of patients, a definitive statement on the effectiveness can be hardly made. This results in the need for prospective multicenter studies that allow clear recommendations for systemic therapy of the tumor. The present paper gives an overview of the sub-cellular and genetic characteristics of ACC, which represent possible targets for systemic therapies and have partly already been included in running clinical trials.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Carcinoma, Adenoid Cystic genetics
Carcinoma, Adenoid Cystic pathology
DNA Mutational Analysis
Genetic Therapy methods
Humans
Immunologic Factors therapeutic use
Immunotherapy
Precision Medicine
Signal Transduction drug effects
Antineoplastic Agents therapeutic use
Biological Products therapeutic use
Carcinoma, Adenoid Cystic drug therapy
Genetic Markers genetics
Molecular Targeted Therapy
Otorhinolaryngologic Neoplasms therapy
Subjects
Details
- Language :
- German
- ISSN :
- 1438-8685
- Volume :
- 93
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Laryngo- rhino- otologie
- Publication Type :
- Academic Journal
- Accession number :
- 25302595
- Full Text :
- https://doi.org/10.1055/s-0034-1382024