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Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring".
- Source :
-
Science (New York, N.Y.) [Science] 2014 Oct 10; Vol. 346 (6206), pp. 176. - Publication Year :
- 2014
-
Abstract
- Tyzio et al. (Reports, 7 February 2014, p. 675) reported that bumetanide restored the impaired oxytocin-mediated γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery in animal models of autism, ameliorating some autistic-like characteristics in the offspring. However, standard practices in the study of these models, such as the use of sex-dimorphic or males-only analyses and implementation of tests measuring social behavior, are lacking to definitely associate their findings to autism.<br /> (Copyright © 2014, American Association for the Advancement of Science.)
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 346
- Issue :
- 6206
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 25301610
- Full Text :
- https://doi.org/10.1126/science.1255679