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Genetic ancestry influences asthma susceptibility and lung function among Latinos.

Authors :
Pino-Yanes M
Thakur N
Gignoux CR
Galanter JM
Roth LA
Eng C
Nishimura KK
Oh SS
Vora H
Huntsman S
Nguyen EA
Hu D
Drake KA
Conti DV
Moreno-Estrada A
Sandoval K
Winkler CA
Borrell LN
Lurmann F
Islam TS
Davis A
Farber HJ
Meade K
Avila PC
Serebrisky D
Bibbins-Domingo K
Lenoir MA
Ford JG
Brigino-Buenaventura E
Rodriguez-Cintron W
Thyne SM
Sen S
Rodriguez-Santana JR
Bustamante CD
Williams LK
Gilliland FD
Gauderman WJ
Kumar R
Torgerson DG
Burchard EG
Source :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2015 Jan; Vol. 135 (1), pp. 228-35. Date of Electronic Publication: 2014 Oct 06.
Publication Year :
2015

Abstract

Background: Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest.<br />Objective: To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children.<br />Methods: We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry.<br />Results: Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10(-15)), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P = .001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10(-5) and -83 ± 19 mL; P = 1.1 x 10(-5), respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10(-6) and -107 ± 22 mL; P = 1.0 x 10(-6), respectively).<br />Conclusion: Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.<br /> (Copyright © 2014 American Academy of Allergy, Asthma & Immunology. All rights reserved.)

Details

Language :
English
ISSN :
1097-6825
Volume :
135
Issue :
1
Database :
MEDLINE
Journal :
The Journal of allergy and clinical immunology
Publication Type :
Academic Journal
Accession number :
25301036
Full Text :
https://doi.org/10.1016/j.jaci.2014.07.053