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The disconnect between a national tuberculosis drug resistance survey and treatment outcomes: a lost opportunity.

Authors :
Click ES
Chirenda J
Kibias S
Menzies HJ
Oeltmann JE
Sentle C
Muribe T
Lere TD
Makombe R
Bamrah S
Moore BK
Cain KP
Source :
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2014 Nov; Vol. 18 (11), pp. 1319-22.
Publication Year :
2014

Abstract

We linked results from the Fourth Botswana National Drug Resistance Survey (DRS), 2007-2008, to patient records from the national Electronic Tuberculosis Registry to determine treatment outcomes. Of 915 new patients, 651 (71%) had treatment data available. Completion or cure was achieved for 10/15 (67%, 95%CI 42-85) with isoniazid monoresistance, (6/16, 38%, 95%CI 18-61) with multidrug resistance, while 73% (391/537, 95%CI 69-76) were susceptible to first-line drugs. The analysis was limited because of unavailable treatment records and undocumented outcomes. Prospective analyses following DRSs should be considered to ensure adequate outcome data.

Details

Language :
English
ISSN :
1815-7920
Volume :
18
Issue :
11
Database :
MEDLINE
Journal :
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Publication Type :
Academic Journal
Accession number :
25299864
Full Text :
https://doi.org/10.5588/ijtld.13.0710