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Post-transplant lymphoproliferative disorders are not associated with IgG4 sclerosing disease.
- Source :
-
Transplant infectious disease : an official journal of the Transplantation Society [Transpl Infect Dis] 2014 Dec; Vol. 16 (6), pp. 897-903. Date of Electronic Publication: 2014 Oct 09. - Publication Year :
- 2014
-
Abstract
- Background: Although the majority of post-transplant lymphoproliferative disorder (PTLD) cases are associated with Epstein-Barr virus (EBV), 20-42% of cases are EBV negative (EBV-N). The antigenic stimulus that drives EBV-N PTLD is unknown, but is likely heterogeneous. A common feature of PTLD, regardless of EBV status, is an abnormal polytypic lymphoplasmacytic infiltrate. Immunglobulin-G4 (IgG4) syndrome is also characterized by a polytypic lymphoplasmacytic infiltrate with a predominance of IgG4-positive (IgG4-P) plasma cells.<br />Methods: We investigated the possibility of an association between EBV-N PTLD and IgG4 syndrome. Of 33 evaluated PTLD cases, 9 (27%) were EBV-N. EBV-N PTLD cases showed longer transplantation-to-diagnosis times than EBV-positive cases.<br />Results: A single patient had a preceding benign duodenal biopsy with focally prominent IgG4-P plasma cells; however, no clinical data supported IgG4 syndrome, precluding an association between IgG4 syndrome and subsequent EBV-N PTLD in this patient.<br />Conclusion: As none of 29 evaluable cases of PTLD (including all 9 EBV-N cases) were associated with an increase in IgG4-P plasma cells, IgG4 syndrome does not appear to play a role in the etiology of EBV-N PTLD. The significance of these findings and the current understanding of the etiology of EBV-N PTLD are discussed.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Epstein-Barr Virus Infections complications
Female
Humans
Lymphoproliferative Disorders diagnosis
Male
Middle Aged
Organ Transplantation adverse effects
Pilot Projects
Postoperative Complications
Retrospective Studies
Risk Factors
Scleroderma, Systemic etiology
Scleroderma, Systemic pathology
Young Adult
Immunoglobulin G metabolism
Lymphoproliferative Disorders etiology
Scleroderma, Systemic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3062
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Transplant infectious disease : an official journal of the Transplantation Society
- Publication Type :
- Academic Journal
- Accession number :
- 25298125
- Full Text :
- https://doi.org/10.1111/tid.12300