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FGF23 is associated with disease severity and prognosis in chronic heart failure.
- Source :
-
European journal of clinical investigation [Eur J Clin Invest] 2014 Dec; Vol. 44 (12), pp. 1150-8. Date of Electronic Publication: 2014 Nov 03. - Publication Year :
- 2014
-
Abstract
- Background: Elevated levels of fibroblast growth factor 23 (FGF23) are associated with incident heart failure in individuals with or without chronic kidney disease. We aimed to investigate the association between serum FGF23 concentrations and disease severity and long-term outcome in patients with stable heart failure.<br />Materials and Methods: Serum levels of C-term FGF23 (Ct-FGF23) concentrations, inorganic phosphate (Pi ), parathormone (PTH) and 25-hydroxyvitamin D (25(OH)D) were measured in 208 patients with nonischaemic heart failure (age 48 ± 15 years; 70% male; NYHA Class I 27·8%, NYHA Class II 43·4%, NYHA Class III/IV 28·8%; LV-EF 34 ± 15%; eGFR ≥60 mL/min/1·73 m(2) in 86%).<br />Results: Median Ct-FGF23 levels were 18·2 RU/mL (7·5-40·8RU/mL). A dose-response relationship was found between median Ct-FGF23 levels and increasing NYHA class (I: 11·9 RU/mL, II: 15·8 RU/mL, III/IV: 38·8 RU/mL; P < 0·001). Ct-FGF23 correlated with NTproBNP (r = 0·307, P < 0·001), central venous pressure, mean pulmonary arterial pressure, pulmonary capillary wedge pressure and inversely correlated with cardiac output after adjustment for renal function (eGFR) and Pi . LnCt-FGF23 was related with the combined endpoint of death or heart transplantation (hazard ratio 1·452 [1·029-2·048]; P = 0·034) independent of Pi , PTH, 25(OH)D, age and sex.<br />Conclusion: The phosphatonin FGF23 is strongly associated with disease severity and long-term outcome in patients with nonischaemic heart failure and preserved renal function. Further studies are needed to evaluate the pathophysiologic role of FGF23 and its potential as a biomarker in heart failure.<br /> (© 2014 Stichting European Society for Clinical Investigation Journal Foundation.)
- Subjects :
- Adult
Biomarkers metabolism
Chronic Disease
Female
Fibroblast Growth Factor-23
Glomerular Filtration Rate physiology
Heart Failure physiopathology
Hemodynamics physiology
Humans
Male
Middle Aged
Parathyroid Hormone metabolism
Phosphates metabolism
Prognosis
Retrospective Studies
Sex Factors
Vitamin D analogs & derivatives
Vitamin D metabolism
Fibroblast Growth Factors metabolism
Heart Failure mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2362
- Volume :
- 44
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- European journal of clinical investigation
- Publication Type :
- Academic Journal
- Accession number :
- 25294008
- Full Text :
- https://doi.org/10.1111/eci.12349