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A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.
- Source :
-
Annual review of pharmacology and toxicology [Annu Rev Pharmacol Toxicol] 2015; Vol. 55, pp. 107-27. Date of Electronic Publication: 2014 Sep 29. - Publication Year :
- 2015
-
Abstract
- Asian Americans are one of the fastest-growing populations in the United States. A relatively large subset of this population carries a unique loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2. Found in approximately 560 million people of East Asian descent, ALDH2*2 reduces enzymatic activity by approximately 60% to 80% in heterozygotes. Furthermore, this variant is associated with a higher risk for several diseases affecting many organ systems, including a particularly high incidence relative to the general population of esophageal cancer, myocardial infarction, and osteoporosis. In this review, we discuss the pathophysiology associated with the ALDH2*2 variant, describe why this variant needs to be considered when selecting drug treatments, and suggest a personalized medicine approach for Asian American carriers of this variant. We also discuss future clinical and translational perspectives regarding ALDH2*2 research.
- Subjects :
- Aldehyde Dehydrogenase metabolism
Aldehyde Dehydrogenase, Mitochondrial
Animals
DNA Mutational Analysis
Decision Support Techniques
Drug-Related Side Effects and Adverse Reactions enzymology
Drug-Related Side Effects and Adverse Reactions ethnology
Drug-Related Side Effects and Adverse Reactions genetics
Drug-Related Side Effects and Adverse Reactions prevention & control
Gene Frequency
Genetic Predisposition to Disease
Genetic Testing methods
Humans
Patient Safety
Patient Selection
Pharmacokinetics
Phenotype
Predictive Value of Tests
Risk Assessment
Risk Factors
Aldehyde Dehydrogenase genetics
Asian genetics
Pharmacogenetics methods
Point Mutation
Precision Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 1545-4304
- Volume :
- 55
- Database :
- MEDLINE
- Journal :
- Annual review of pharmacology and toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 25292432
- Full Text :
- https://doi.org/10.1146/annurev-pharmtox-010814-124915