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The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2014 Oct 20; Vol. 211 (11), pp. 2169-81. Date of Electronic Publication: 2014 Oct 06. - Publication Year :
- 2014
-
Abstract
- Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B cell program, including BCL6 and PAX5, and plasma cell-promoting factors, such as IRF4 and BLIMP-1. We show that the complex of IRF8 and PU.1 controls the propensity of B cells to undergo CSR and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1. As the PU.1-IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation.<br /> (© 2014 Carotta et al.)
- Subjects :
- Animals
Cell Line
Cluster Analysis
Gene Expression Profiling
Gene Expression Regulation
Humans
Immunoglobulin Class Switching genetics
Interferon Regulatory Factors metabolism
Mice
Mice, Transgenic
Plasma Cells immunology
Protein Binding
Proto-Oncogene Proteins metabolism
Trans-Activators metabolism
Cell Differentiation genetics
Interferon Regulatory Factors genetics
Plasma Cells cytology
Plasma Cells metabolism
Proto-Oncogene Proteins genetics
Trans-Activators genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 211
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25288399
- Full Text :
- https://doi.org/10.1084/jem.20140425