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Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species.
- Source :
-
Organic letters [Org Lett] 2014 Oct 17; Vol. 16 (20), pp. 5366-9. Date of Electronic Publication: 2014 Oct 06. - Publication Year :
- 2014
-
Abstract
- The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.
- Subjects :
- Actinomyces drug effects
Alkaloids chemistry
Animals
Anti-Bacterial Agents chemistry
Bacteroides drug effects
Indole Alkaloids
Marine Biology
Microbial Sensitivity Tests
Mitosporic Fungi
Molecular Structure
Peptostreptococcus drug effects
Streptococcus drug effects
Tinidazole pharmacology
Veillonella drug effects
Alkaloids isolation & purification
Alkaloids pharmacology
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Ascomycota chemistry
Perciformes microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 25286294
- Full Text :
- https://doi.org/10.1021/ol502572g