Back to Search
Start Over
Collagen membranes prevent apical migration of epithelium and support new connective tissue attachment during periodontal wound healing in dogs.
- Source :
-
Journal of periodontal research [J Periodontal Res] 1989 Jul; Vol. 24 (4), pp. 247-53. - Publication Year :
- 1989
-
Abstract
- The capacity of collagen membranes to prevent the apical migration of epithelium and to support new connective tissue attachment was assessed in experimental periodontal defects in dogs. Experimental periodontal defects were produced in 8 mongrel dogs by removing the alveolar bone and the periodontal ligament over the most coronal 5 mm of the labial aspect of the maxillary canines. Experimental defects associated with the right canine and its surrounding bone were covered by collagen membranes prepared by air drying gels of rat type I fibrillar collagen. Flaps were repositioned and sutured. The contralateral control defects were sham-operated without using collagen membranes. Animals were killed, 10 and 30 days after surgery, 4 at each time point. The experimental and control sites were processed for histologic and histomorphometric evaluation. At 10 d, the average distance between the apical margin of the epithelium and the apical level of the defect (EA) sites was 3.20 +/- 0.55 mm for the experimental sites and 0.73 +/- 0.18 mm for the controls. The experimental root surfaces apical to the epithelium and the collagen membranes were covered by connective tissue cells. At 30 d, the EA for experimental and control sites were 2.55 +/- 0.36 mm and 0.47 +/- 0.30 mm, respectively. In the experimental sites healing by long junctional epithelium was observed in the coronal 40% of apico-occlusal dimension of the defect and new connective tissue attachment with inserting fibers in the apical 55% of the defect length. No new bone formation was observed. In the control sites, pocket formation was found in the most coronal one-third of the defect.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Animals
Cell Movement
Connective Tissue physiology
Connective Tissue Cells
Dental Cementum pathology
Dogs
Epithelial Attachment pathology
Epithelial Cells
Epithelium physiology
Periodontal Diseases pathology
Periodontium pathology
Rats
Wound Healing
Collagen
Membranes, Artificial
Periodontal Diseases physiopathology
Periodontium physiology
Regeneration
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3484
- Volume :
- 24
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of periodontal research
- Publication Type :
- Academic Journal
- Accession number :
- 2528624
- Full Text :
- https://doi.org/10.1111/j.1600-0765.1989.tb01789.x