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The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study.
- Source :
-
AIDS and behavior [AIDS Behav] 2014 Dec; Vol. 18 (12), pp. 2285-90. - Publication Year :
- 2014
-
Abstract
- In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.
Details
- Language :
- English
- ISSN :
- 1573-3254
- Volume :
- 18
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- AIDS and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 25280447
- Full Text :
- https://doi.org/10.1007/s10461-014-0905-x