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Transforming growth factor-β (TGF-β) expression is increased in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome.
- Source :
-
PloS one [PLoS One] 2014 Sep 30; Vol. 9 (9), pp. e108312. Date of Electronic Publication: 2014 Sep 30 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Carpal tunnel syndrome (CTS) is an idiopathic disease that results from increased fibrosis of the subsynovial connective tissue (SSCT). A recent study found overexpression of both transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) in the SSCT of CTS patients. This study investigated TGF-β and CTGF expression in a rabbit model of CTS, in which SSCT fibrosis is induced by a surgical injury. Levels of TGF-β1 and CTGF at 6, 12, 24 weeks after injury were determined by immunohistochemistry A significant increase in TGF-β1 and a concomitant significant increase in CTGF were found at 6 weeks, in addition to higher cell density compared to normal (all p<0.05), Interestingly, CTGF expression was reduced at 12 and 24 weeks, suggesting that an initial insult results in a time limited response. We conclude that this rabbit model mimics the fibrosis found in human CTS, and may be useful to study pathogenetic mechanisms of CTS in vivo.
- Subjects :
- Animals
Carpal Tunnel Syndrome metabolism
Carpal Tunnel Syndrome pathology
Cell Count
Connective Tissue injuries
Connective Tissue metabolism
Connective Tissue pathology
Connective Tissue Growth Factor metabolism
Female
Fibroblasts metabolism
Fibroblasts pathology
Fibrosis
Gene Expression
Humans
Metacarpus injuries
Metacarpus metabolism
Metacarpus pathology
Transforming Growth Factor beta1 metabolism
Carpal Tunnel Syndrome genetics
Connective Tissue Growth Factor genetics
Disease Models, Animal
Rabbits
Transforming Growth Factor beta1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 25269071
- Full Text :
- https://doi.org/10.1371/journal.pone.0108312