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Therapeutic potential of umbilical cord mesenchymal stem cells with Wnt/β-catenin signaling pathway pre-activated for the treatment of diabetic wounds.
- Source :
-
European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2014; Vol. 18 (17), pp. 2460-4. - Publication Year :
- 2014
-
Abstract
- The pathogenesis of diabetes mellitus wounds is complicate, and there lacks effective treatment strategies. Mesenchymal stem cells can promote wound healing. Compared with bone marrow mesenchymal stem cells, umbilical cord mesenchymal stem cells have obvious advantages in biological property. Wnts are potent regulatory molecules for stem cell turnover and skin regeneration, while Wnt signaling is not well activated in diabetic wounds. Umbilical cord mesenchymal stem cells with Wnt/β-catenin signaling pathway pre-activated have some potential in the treatment of diabetic wounds. In this paper, we review the research status as well as problems in this field.
- Subjects :
- Animals
Humans
Mesenchymal Stem Cells metabolism
Signal Transduction
Umbilical Cord metabolism
Diabetes Mellitus pathology
Diabetes Mellitus therapy
Mesenchymal Stem Cell Transplantation methods
Mesenchymal Stem Cells cytology
Skin pathology
Umbilical Cord cytology
Wnt Signaling Pathway
Wound Healing physiology
beta Catenin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2284-0729
- Volume :
- 18
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- European review for medical and pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25268090