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Electroencephalogram reactivity to verbal command after dexmedetomidine, propofol and sevoflurane-induced unresponsiveness.
- Source :
-
Anaesthesia [Anaesthesia] 2015 Feb; Vol. 70 (2), pp. 190-204. Date of Electronic Publication: 2014 Sep 29. - Publication Year :
- 2015
-
Abstract
- Although electroencephalogram reactivity (i.e. transient changes in electrical brain activity following external stimulus) might be useful in depth-of-anaesthesia monitoring, it has not been systematically examined with different anaesthetics at doses titrated to unresponsiveness. Three 10-subject groups of healthy volunteers received dexmedetomidine, propofol or sevoflurane in escalating pseudo-steady-state concentrations at 10-min intervals until they did not open their eyes to command. The electroencephalogram was continuously recorded and spectral variables were calculated with short-time Fourier transform and time-varying autoregressive modelling. Electroencephalogram reactivity was most prominent in the midfrontal derivations (termed F3 and F4). During drug-induced unresponsiveness, electroencephalogram reactivity was still present in all drug groups. Dexmedetomidine, propofol and sevoflurane induced distinct suppression patterns on the electroencephalogram reactivity at the same clinical endpoint (unresponsiveness). Reactivity was best maintained with propofol, while only minimally preserved with dexmedetomidine and sevoflurane. Thus, it may be difficult to harness reactivity for depth-of-anaesthesia monitoring.<br /> (© 2014 The Association of Anaesthetists of Great Britain and Ireland.)
- Subjects :
- Adult
Anesthesia Recovery Period
Anesthetics, Inhalation pharmacology
Anesthetics, Intravenous pharmacology
Fourier Analysis
Humans
Hypnotics and Sedatives pharmacology
Male
Sevoflurane
Young Adult
Deep Sedation methods
Dexmedetomidine pharmacology
Electroencephalography drug effects
Methyl Ethers pharmacology
Propofol pharmacology
Verbal Behavior drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2044
- Volume :
- 70
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Anaesthesia
- Publication Type :
- Academic Journal
- Accession number :
- 25266086
- Full Text :
- https://doi.org/10.1111/anae.12868